Optical property changes in ex-vivo tissue exposed to high intensity focused ultrasound


Baseline changes in optical properties have been previously measured as a function of thermal-dose for tissues exposed to a temperature-controlled water bath (doi:10.1088/0031-9155/59/13/3249). In this work, the wavelength-dependent optical scattering and absorption of ex vivo tissues exposed to HIFU is measured using an integrating sphere spectrophotometric technique employed previously. HIFU-induced spatiotemporal temperature elevations are measured using an infrared camera and used to calculate the thermal dose delivered to a localized region of tissue. We consider the impact of thermal dose, temperature elevation, and heating rate on the formation of HIFU lesions and the resulting changes in tissue optical properties.  [Work supported by the ASA F.V. Hunt Fellowship and the University of Oxford.]



Prof. Robin Cleveland, Institute of Biomedical Engineering, University of Oxford  

Recent Publications and Presentations

  • Raymond JL, Cleveland RO, Roy RA. Optical properties of tissue exposed to high-intensity focused ultrasound. Submitted to Physics in Medicine and Biology, July, 2018.
  • Raymond JL, Cleveland RO, Roy RA. Changes in the optical scattering and absorption spectra of ex-vivo chicken breast tissue following exposure to HIFU. Proceedings - 17th International Symposium on Therapeutic Ultrasound 2017, J. Therapeutic Ultrasound 6(Suppl 1):2, 40. doi:10.1186/s40349-018-0110-x
  • Raymond, J.L., Edwards, E., Cleveland, R.O. and Roy, R.A., “Optical property changes in ex vivo tissues exposed to high‐intensity focused ultrasound,” presented at the 171st meeting of the Acoustical Society of America, Salt Lake City, UT, May 2016 J. Acoust. Soc. Am. 139, 2029 (2016).
  • Adams, M., Wang, Q., Cleveland, R.O., and Roy, R.A., “Thermal dose dependent optical property changes of ex vivo chicken breast tissues between 500 and 1100 nm,” Phys. Med. Biol. 59, 3249-3260 (2014).